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Contraindications for Suboxone Compromised respiratory function Hypersensitivity or allergy to buprenorphine or naloxone Taking benzodiazepines or other CNS depressants, antiretrovirals, serotonergic drugs or CYP3A4 inhibitors or inducers Studies have generally shown Suboxone as safe for pregnant and breastfeeding individuals

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The rectal delivery system includes a plastic applicator with a flexible, molded tip available in two lengths, designated for convenience as 10 mg Delivery System and 20 mg Delivery System